Citrus and Eucalyptus Essential Oils for Alzheimer’s

Managing the day-to-day realities of neurodegenerative conditions like Alzheimer's and dementia can be an uphill task for patients and their loved ones. However, in the areas of nutrition and aromatherapy, credible research has proven effectiveness of alternative approaches.

This is a particularly relevant topic for the owner of Earth Solutions, physician David Epstein, D.O. who operates a telemedicine website testing and treating nutrient balances, inflammation  toxic overload to reduce progression of this condition. Readers of this post may wish to learn more about his utilization of the Dale Bredesen, M.D. approach.

Aromatherapy and specific key essential oils also offer promise in treating neurodegenerative disorders such as Alzheimer's Disease. Recent research referenced below shows that various essential oil and their terpenes effect a very specific issue in persons with this disorder:

Eucalyptus Oil Alzheimer's and Dementia; Terpenes Antioxidant and Antiacetylcholinesterase Properties

In a popularly cited Moroccan research study, it was found that eucalyptus oil, notably from the species Eucalyptus globulus, was found to have significant anti-acetylcholinesterase (AChE) properties in research on commercial essential oils. Acetylcholinesterase is an enzyme that breaks down acetylcholine, a vital neurotransmitter involved in nerve signal transmission, particularly in the brain. In Alzheimer's disease, acetylcholine levels in the brain are significantly reduced, impairing cognitive functions. By inhibiting AChE, eucalyptus oil may help prevent the breakdown of acetylcholine, thereby potentially ameliorating some symptoms of Alzheimer's.

Interestingly, eucalyptus oil's AChE inhibition is not solely due to its major terpene components, 1,8-cineole and limonene, but to other compounds present as well, such as δ-3-carene. Despite its overall lower antioxidant activity compared to oils like Thymus vulgaris (thyme), eucalyptus was superior in terms of AChE inhibition.

Among the five oils tested in the study, Thymus vulgaris L. oil emerged as the top contender for antioxidant activity. The presence of key compounds, thymol and carvacrol, seems to underline its superior antioxidant activity.

The cited study used steam-distilled eucalyptus oil for in vitro tests, implying that the method of application in humans (inhalation or topical) was not directly addressed. However, the bioactive compounds in eucalyptus oil can potentially be absorbed through both methods.

This finding is part of a broader interest in harnessing natural antioxidants to mitigate oxidative stress, a key factor in neurodegenerative diseases. Antioxidants can "absorb" reactive oxygen species (ROS), preventing them from causing cellular damage. Essential oils like eucalyptus can serve as natural sources of such antioxidants, suggesting possible therapeutic potential in managing conditions like Alzheimer's.

Harnessing the Antioxidant Properties of Essential Oils

Neurodegenerative disorders, such as Alzheimer's disease and dementia, are associated with oxidative stress. Oxidative stress is a state of imbalance between the production of free radicals (highly reactive and unstable molecules that can cause damage to cells) and the body's ability to counteract or neutralize their harmful effects through neutralization by antioxidants.

Oxidative stress can lead to cellular damage, including damage to neurons, the primary cells of the brain and nervous system. Over time, this oxidative damage can contribute to the development and progression of neurodegenerative diseases.

Antioxidants are substances that help protect the body from oxidative stress by neutralizing free radicals, thus reducing their potential for cellular damage. Antioxidants include a range of substances, many of which are found in fruits, vegetables, and other plant-based foods. They can also be found in certain essential oils.

Research has suggested that antioxidants may play a protective role in neurodegenerative diseases. They may help to limit neuronal damage, reduce inflammation, and potentially slow the progression of these diseases.

For example, certain essential oils such as lemon balm (Melissa officinalis) and rosemary (Rosmarinus officinalis) have been found to possess antioxidant properties. These oils may contribute to reducing oxidative stress, potentially providing a supportive role in the context of neurodegenerative diseases.

This property is being explored in the context of neurodegenerative diseases to see how it might help in managing symptoms and supporting overall wellbeing [Perry & Perry, 2006; Mitchell, 1993].